After 21 minutes of the hour-long session at Zandvoort, Leclerc was the first and only rider to drop below the 1:11 mark when he ran for the top of the timekeeping.
The Ferrari driver set a benchmark of 1: 10.902 seconds to defeat Ocon before Leclerc was quickly followed by teammate Carlos Sainz Jr.
It was a full sixth-tenth win over Hamilton’s bar from the first morning’s practice run.
The start of the afternoon session was delayed by five minutes, although the full running time was still allowed and Kimi Raikkonen was the first driver on the track.
He was followed by Sergio Perez and Nikita Mazepin as all drivers apart from McLarens, Williams, Fernando Alonso and Pierre Gasly (C1, Hards) opted for the yellow C2 tires initially.
Raikkonen led his Alfa Romeo over the finish line in 1: 14.256 minutes, but was quickly beaten back by seven tenths by the Red Bull of Perez.
Valtteri Bottas then took the lead after just four minutes and drove his Mercedes around in 1: 11.66 minutes to find four tenths ahead of the Ferraris.
Hamilton’s first run was completed in 1: 111.911 minutes and he climbed to second place, but his day ended shortly after when he took the red flags after just six minutes.
The seven-time F1 champion reported a loss of power, allegedly due to an irregular oil supply, and was instructed to stop his Mercedes on the right-hand bend of Turn 8 across the track, which was greeted with cheers from the stands.
Marshals support Lewis Hamilton, Mercedes, after a breakdown in FP2
Photo by: Charles Coates / Motorsport Images
Hamilton’s car was pushed onto an escape route and the session was resumed with an eight minute delay, but the Briton refused to resume and was eventually put on Nov.
Sainz had led the line in the pit lane as the field waited for the green light before Ocon and Red Bull’s home favorite Max Verstappen quickly moved up to second and third place behind Bottas.
A minute later, Sebastian Vettel returned to the track with 45 minutes to go after a suspected ERS error in opening training had left the sidelines for a long time.
39 minutes before the end and probably in response to the shortened run for Hamilton, Bottas was switched to the C3 soft tires with red walls early on in order to start the qualifying runs.
The Finn ran for a time of 1: 11.664 minutes to confirm his lead at the top of the times before Alpine racing driver Ocon completed an impressive flying lap with a time of 1: 11.074 seconds.
Despite renewed efforts by Mercedes driver Bottas, he was only able to reduce the gap to Ocon to 0.058 seconds when Alonso moved up into third place ahead of Pierre Gasly.
Alonso ran 0.495 seconds behind his teammate, who set the pace before a second red flag interrupted the run.
Mazepin made the second stop halfway through the session when he lost the rear of his Haas at the entrance to the 90-degree right-hand bend of Turn 11 and the car ran aground in the gravel.
The Ferraris quickly climbed to the front of the field when they started again, but the interrupted program led to a comparatively early end of the qualifying simulations.
Max Verstappen, Red Bull Racing RB16B
Photo by: Charles Coates / Motorsport Images
Leclerc led Sainz and Ocon, while Bottas finished fourth ahead of Verstappen, who finished the day with a best time of 1: 11.264 minutes and was 0.362 seconds behind the Ferraris.
But the majority of the race for Verstappen was dedicated to the races, and he consistently delivered 1: 15.1 to 1: 15.4 seconds over the last quarter of an hour.
Alonso and Gasly were gradually pushed back to sixth and seventh places, while Lando Norris moved to the softs to beat Antonio Giovinazzi’s Alfa Romeo to eighth place.
Vettel regained some lost ground when he finished 10th, with Hamilton’s early run enough to stop 12th fastest Sergio Perez.
George Russell, who took his first F1 podium at Spa last weekend, was the slowest on board his Williams with a performance of 1: 12.955 seconds.
